Dr. David Sinclair: The Biology of Slowing & Reversing Aging
from Huberman Lab
by Scicomm Media
Published: Mon Dec 27 2021
Show Notes
In this episode, I am joined by Dr. David Sinclair, tenured Professor of Genetics at Harvard Medical School and an expert researcher in the field of longevity. Dr. Sinclair is also the author of the book Lifespan: Why We Age & Why We Don't Have To, and the host of the Lifespan Podcast, which launches January 5, 2022.
In this interview, we discuss the cellular and molecular mechanisms of aging and what we all can do to slow or reverse the aging process. We discuss fasting and supplementation with resveratrol, NAD, metformin, and NMN. We also discuss the use of caffeine, exercise, cold exposure, and why excessive iron load is bad for us. We discuss food choices for offsetting aging and promoting autophagy (clearance of dead cells). And we discuss the key blood markers everyone should monitor to determine your biological versus chronological age. We also discuss the future of longevity research and technology. This episode includes lots of basic science and specific, actionable protocols, right down to the details of what to do and when. By the end, you will have in-depth knowledge of the biology of aging and how to offset it.
Read the full show notes for this episode at hubermanlab.com.
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Timestamps
Dr. David Sinclair, Harvard Medical School
Sponsors: AG1, LMNT & Waking Up
“Aging as a Disease” vs. Longevity & Anti-Aging
What Causes Aging? The Epigenome
Cosmetic Aging
Development Never Stops, Horvath Clock
Puberty Rate as a Determinant of Aging Rate
Fasting, Hunger & Food Choices
Fasting Schedules, Long Fasts, (Macro)Autophagy
Caffeine, Electrolytes
Blood Glucose & the Sirtuins; mTOR
Amino Acids: Leucine, “Pulsing”
Metformin, Berberine
Resveratrol, Wine
What Breaks a Fast?
Resveratrol, NAD, NMN, NR; Dosage, Timing
Are Artificial Sweeteners Bad for Us?
Iron Load & Aging
Blood Work Analysis
C-Reactive Protein, Cholesterol: Serum & Dietary
Amino Acids, Plants, Antioxidants
Behaviors That Extend Lifespan, Testosterone, Estrogen
Neuroplasticity & Neural Repair
Ice Baths, Cold Showers, “Metabolic Winter”
Obesity & How It Accelerates Aging, GnRH
Methylation, Methylene Blue, Cigarettes
X-Rays
Public Science Education, Personal Health
The Sinclair Test You Can Take: www.doctorsinclair.com
Zero-Cost Support & Resources, Sponsors, Supplements, Instagram