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Journal Club with Dr. Peter Attia | Effects of Light & Dark on Mental Health & Treatments for Cancer by Scicomm Media

Journal Club with Dr. Peter Attia | Effects of Light & Dark on Mental Health & Treatments for Cancer

from Huberman Lab

by Scicomm Media

Published: Mon Jan 22 2024

Show Notes

In this journal club episode, my guest is Dr. Peter Attia, M.D., a Stanford and Johns Hopkins-trained physician focusing on healthspan and lifespan and the host of The Drive podcast.

We each present a peer-reviewed scientific paper chosen because it contains novel, interesting, and actionable data. First, we discuss a paper on how bright light exposure at sunrise and throughout the day and dark exposure at night independently improve mental health and can offset some of the major symptoms of mental health disorders such as depression and anxiety. Then, we discuss an article that explores a novel class of immunotherapy treatments to combat cancer. We also discuss some of the new data on low-calorie sweeteners and if they are safe. This episode should be of interest to listeners curious about maximizing their vitality and longevity and to anyone seeking science-supported ways to improve mental health and lifespan.

Read the full shotes for this episode at hubermanlab.com.

Thank you to our sponsors

AG1: https://drinkag1.com/huberman

LMNT: https://drinklmnt.com/hubermanlab

Timestamps

Dr. Peter Attia, Journal Club

Sponsors: LMNT & Waking Up

Light, Dark & Mental Health; Retina

Outdoor vs. Indoor Light, Cataracts, Sunglasses

Tools: Sunrise & Sunsets, Circadian Rhythm; Midday Light

Tools: Night & Light Exposure; Waking Before Sunrise

Article #1, Light/Dark Exposure & Mental Health

Sponsor: AG1

Odds Ratio, Hazard Ratio

Night vs. Daylight Exposure, Mental Health Disorders

Major Depression & Light Exposure; Error Bars & Significance

Prescriptions; Environmental & Artificial Light; Red Lights

Nighttime Light Exposure; Sleep Trackers & Belief Effects

Light Directionality, Phone, Night

Light Wavelengths & Sensors; Sunglasses

Hawthorne Effect, Reverse Causality, Genetics

Artificial Sweeteners, Appetite

Natural Light Cycles, Circadian Rhythm & Mental Health

Article #2, Immune System & Cancer

T-Cell Activation; Viruses

Autoimmunity; Cancer & Immune System Evasion

Checkpoint Inhibitors, CTLA-4

Anti-CTLA-4 Study Drug Ipilimumab, Melanoma

Patient Population, Randomization, GP100

Response Rate

Overall Survival & Response

Median Survival vs. Overall Survival, Drug Development

Gender & Dose

Adverse Events; Autoimmunity

Pancreatic Cancer; Aging & Immune System Health

Melanoma; Lynch Syndrome, Keytruda

Immunotherapy & Cancer Treatment; Melanoma Risk

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