Obesity and the new science of weight loss | Dr. Louis J Aronne

Obesity is a physiological condition that can be managed with the right education and treatment.

In today's episode, Dr. Louis J. Aronne, a leading expert in obesity research, sheds light on the science behind weight management and obesity treatment.

Dr. Aronne dives into groundbreaking weight loss medications. He also explores how lifestyle and eating habits affect long-term health and why medications combined with dietary changes can unlock transformative results.

Louis J. Aronne, M.D. is a leading authority on obesity and its treatment. He’s a former president of The Obesity Society, which publishes the peer-reviewed scientific journal Obesity, of which Dr. Aronne is an associate editor. He has also authored more than 60 papers and book chapters on the topic.

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Timecodes

00:00Introduction

01:01Quickfire questions

03:51What is obesity?

05:06What’s the difference between overweight and obesity?

07:38Why has there been such a quick rise in obesity?

10:55Why it’s not just a lack of willpower

13:50The complexity of weight regulation

15:54What is Leptin and why is it so important for weight control?

19:51The brain’s role in weight regulation

20:36Curing obesity in animal studies

22:29Why hunter-gatherers did not gain weight

23:58Natural experiments in weight gain and loss

26:01How medications can cause weight gain

28:42The impact of calorie restriction diets

30:13Reducing diabetes risk through weight loss

34:10Research into medications as a tool for weight loss

38:36How well do weight loss drugs work?

41:38The future of weight loss drugs

43:51Will you regain the weight if you stop taking weight loss drugs?

48:08Can obesity be avoided without the use of drugs?

49:42Concerns about weight loss drugs

Books by our ZOE Scientists:

• Every Body Should Know This by Dr Federica Amati
• Food For Life by Prof. Tim Spector
• Fibre Fuelled by Dr Will Bulsiewicz

Mentioned in today's episode:

• Persistentmetabolic adaptation 6 years after "The Biggest Loser" competition in Obesity
• TheFinnish diabetes prevention study (DPS) in Diabetes Care
• The National Diabetes Prevention Program of the Centers for Disease Control and Prevention (CDC)

Have feedback or a topic you'd like us to cover? Let us know here.

Episode transcripts are available here.